3nhe: Difference between revisions
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{{STRUCTURE_3nhe| PDB=3nhe | SCENE= }} | {{STRUCTURE_3nhe| PDB=3nhe | SCENE= }} | ||
===High Resolution Structure (1.26A) of USP2a in Complex with Ubiquitin=== | ===High Resolution Structure (1.26A) of USP2a in Complex with Ubiquitin=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/UBP2_HUMAN UBP2_HUMAN]] Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells.<ref>PMID:17290220</ref> <ref>PMID:19917254</ref> <ref>PMID:19838211</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3nhe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NHE OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Ubiquitin thiolesterase]] | [[Category: Ubiquitin thiolesterase]] | ||
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[[Category: Hydrolase-protein binding complex]] | [[Category: Hydrolase-protein binding complex]] | ||
[[Category: Substrate enzyme complex]] | [[Category: Substrate enzyme complex]] | ||
