3nkn: Difference between revisions

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~~[[Image:3nkn.jpg|left|200px]]~~

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===Crystal structure of mouse autotaxin in complex with 14:0-LPA===

===~~Crystal structure of mouse autotaxin in complex with 14~~:~~0-LPA==~~=

==Disease==

[[http://www.uniprot.org/uniprot/ENPP2_MOUSE ENPP2_MOUSE]] Note=May contribute to obesity.

==Function==

[[http://www.uniprot.org/uniprot/ENPP2_MOUSE ENPP2_MOUSE]] Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.<ref>PMID:15700135</ref> <ref>PMID:17208043</ref> <ref>PMID:21240269</ref>

==About this Structure==

[[3nkn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NKN OCA].

==Reference==

[[Category: Alkylglycerophosphoethanolamine phosphodiesterase]]

[[Category: Mus musculus]]

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[[Category: Nureki, O.]]

[[Category: Takagi, J.]]

[[Category: Autotaxin]]

[[Category: Enpp2]]

[[Category: Hydrolase]]

[[Category: Lysophosphatidic acid]]

[[Category: Lysophospholipase d]]

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@@ Line 1: / Line 1: @@
-[[Image:3nkn.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3nkn", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3nkn|  PDB=3nkn  |  SCENE=  }}
+===Crystal structure of mouse autotaxin in complex with 14:0-LPA===
-===Crystal structure of mouse autotaxin in complex with 14:0-LPA===
+==Disease==
+[[http://www.uniprot.org/uniprot/ENPP2_MOUSE ENPP2_MOUSE]] Note=May contribute to obesity.
+==Function==
+[[http://www.uniprot.org/uniprot/ENPP2_MOUSE ENPP2_MOUSE]] Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.<ref>PMID:15700135</ref> <ref>PMID:17208043</ref> <ref>PMID:21240269</ref>
 ==About this Structure==
 [[3nkn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NKN OCA].
+==Reference==
+<references group="xtra"/><references/>
 [[Category: Alkylglycerophosphoethanolamine phosphodiesterase]]
 [[Category: Mus musculus]]
@@ Line 22: / Line 21: @@
 [[Category: Nureki, O.]]
 [[Category: Takagi, J.]]
+[[Category: Autotaxin]]
+[[Category: Enpp2]]
+[[Category: Hydrolase]]
+[[Category: Lysophosphatidic acid]]
+[[Category: Lysophospholipase d]]