3ne0: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3ne0| PDB=3ne0 | SCENE= }} | {{STRUCTURE_3ne0| PDB=3ne0 | SCENE= }} | ||
===Structure and functional regulation of RipA, a mycobacterial enzyme essential for daughter cell separation=== | ===Structure and functional regulation of RipA, a mycobacterial enzyme essential for daughter cell separation=== | ||
{{ABSTRACT_PUBMED_20826344}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/O53168_MYCTU O53168_MYCTU]] Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages.<ref>PMID:16495549</ref> <ref>PMID:17919286</ref> <ref>PMID:18463693</ref> <ref>PMID:20826344</ref> <ref>PMID:21864539</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3ne0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NE0 OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020826344</ref><references group="xtra"/><references/> | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Berisio, R.]] | [[Category: Berisio, R.]] | ||
| Line 32: | Line 19: | ||
[[Category: Peptidoglycan]] | [[Category: Peptidoglycan]] | ||
[[Category: Tuberculosis]] | [[Category: Tuberculosis]] | ||