3nih: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
m Protected "3nih" [edit=sysop:move=sysop] |
(No difference)
| |
Revision as of 12:09, 24 April 2013
The structure of UBR box (RIAAA)
Template:ABSTRACT PUBMED 20835240
Function
[UBR1_YEAST] Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
About this Structure
3nih is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
See Also
Reference
- Choi WS, Jeong BC, Joo YJ, Lee MR, Kim J, Eck MJ, Song HK. Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases. Nat Struct Mol Biol. 2010 Sep 12. PMID:20835240 doi:10.1038/nsmb.1907
