Sandbox Reserved 591: Difference between revisions

I would like the page to have a table of contents and the following main sections: Background, Structure (with a jmol image area), Function, Clinical Relevance, and References. Amyloid Precursor Protein (APP) is a major protein associated with Alzheimer’s disease (AD) and was first identified in 1987. It is located on chromosome 21 and has at least 18 exons. AD is characterized as the most common form of dementia that worsens over time. APP is produced in big amounts and is metabolized very quickly. Risk for developing AD increases with age. APP is produced in big amounts and is metabolized very quickly. APP was discovered in 1987 by several laboratories independently using partial protein sequence data. Alzheimer’s disease is caused by accumulation of β-amyloid peptide (Aβ) within the brain. Mutations in critical areas of APP cause familial susceptibility to AD. Over 25 APP mutations have been identified.