4i3q: Difference between revisions
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{{STRUCTURE_4i3q| PDB=4i3q | SCENE= }} | {{STRUCTURE_4i3q| PDB=4i3q | SCENE= }} | ||
===Crystal structure of human CYP3A4 coordinated to a water molecule=== | ===Crystal structure of human CYP3A4 coordinated to a water molecule=== | ||
{{ABSTRACT_PUBMED_23586711}} | |||
==Function== | ==Function== | ||
Revision as of 06:32, 2 May 2013
Crystal structure of human CYP3A4 coordinated to a water molecule
Template:ABSTRACT PUBMED 23586711
Function
[CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.[1]
About this Structure
4i3q is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
