4hyf: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structural basis and SAR for OD 270, a lead stage 1,2,4-triazole based specific Tankyrase1/2 inhibitor===

~~The entry 4hyf is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>

~~Authors~~: ~~Perdreau, H~~.~~, Ekblad, B~~.~~, Voronkov, A~~.~~, Holsworth, D.D., Waaler, J., Drewes, G., Schueler, H~~.~~, Krauss, S~~.~~, Morth, J~~.P.

==About this Structure==

[[4hyf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HYF OCA].

~~Description~~: ~~Structural basis and SAR for OD 270~~, ~~a lead stage 1~~,2,4-~~triazole based specific Tankyrase1/2~~ inhibitor

==Reference==

[[Category: Homo sapiens]]

[[Category: Drewes, G.]]

[[Category: Ekblad, B.]]

[[Category: Holsworth, D D.]]

[[Category: Krauss, S.]]

[[Category: Morth, J P.]]

[[Category: Perdreau, H.]]

[[Category: Schueler, H.]]

[[Category: Voronkov, A.]]

[[Category: Waaler, J.]]

[[Category: Adp-ribosylation]]

[[Category: Ank repeat]]

[[Category: Catalytic fragment]]

[[Category: Chromosomal protein]]

[[Category: Glycosyltransferase]]

[[Category: Parp]]

[[Category: Phosphorylation]]

[[Category: Telomere]]

[[Category: Transferase]]

[[Category: Transferase-transferase inhibitor complex]]

[[Category: Translocation]]

[[Category: Transport]]

[[Category: Wnt-signalling]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4hyf|  PDB=4hyf  |  SCENE=  }}
+===Structural basis and SAR for OD 270, a lead stage 1,2,4-triazole based specific Tankyrase1/2 inhibitor===
+{{ABSTRACT_PUBMED_23473363}}
-The entry 4hyf is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
-Authors: Perdreau, H., Ekblad, B., Voronkov, A., Holsworth, D.D., Waaler, J., Drewes, G., Schueler, H., Krauss, S., Morth, J.P.
+==About this Structure==
+[[4hyf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HYF OCA].
-Description: Structural basis and SAR for OD 270, a lead stage 1,2,4-triazole based specific Tankyrase1/2 inhibitor
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Drewes, G.]]
+[[Category: Ekblad, B.]]
+[[Category: Holsworth, D D.]]
+[[Category: Krauss, S.]]
+[[Category: Morth, J P.]]
+[[Category: Perdreau, H.]]
+[[Category: Schueler, H.]]
+[[Category: Voronkov, A.]]
+[[Category: Waaler, J.]]
+[[Category: Adp-ribosylation]]
+[[Category: Ank repeat]]
+[[Category: Catalytic fragment]]
+[[Category: Chromosomal protein]]
+[[Category: Glycosyltransferase]]
+[[Category: Parp]]
+[[Category: Phosphorylation]]
+[[Category: Telomere]]
+[[Category: Transferase]]
+[[Category: Transferase-transferase inhibitor complex]]
+[[Category: Translocation]]
+[[Category: Transport]]
+[[Category: Wnt-signalling]]