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==Overview==

Chemokines (chemotactic cytokines) comprise a large family of proteins, that recruit and activate leukocytes, giving chemokines a major role in, both immune response and inflammation-related diseases. The, poxvirus-encoded viral CC chemokine inhibitor (vCCI) binds to many CC, chemokines with high affinity, acting as a potent inhibitor of chemokine, action. We have used heteronuclear multidimensional NMR to determine the, structure of an orthopoxvirus vCCI in complex with a human CC chemokine, MIP-1beta (macrophage inflammatory protein 1beta). vCCI binds to the, chemokine with 1:1 stoichiometry, forming a complex of 311 aa. vCCI uses, residues from its beta-sheet II to interact with a surface of MIP-1beta, that includes residues adjacent to its N terminus, as well as residues in, the 20's region and the 40's loop. This structure reveals the strategy, used by vCCI to tightly bind numerous chemokines while retaining, selectivity for the CC chemokine subfamily.

Chemokines (chemotactic cytokines) comprise a large family of proteins that recruit and activate leukocytes, giving chemokines a major role in both immune response and inflammation-related diseases. The poxvirus-encoded viral CC chemokine inhibitor (vCCI) binds to many CC chemokines with high affinity, acting as a potent inhibitor of chemokine action. We have used heteronuclear multidimensional NMR to determine the structure of an orthopoxvirus vCCI in complex with a human CC chemokine, MIP-1beta (macrophage inflammatory protein 1beta). vCCI binds to the chemokine with 1:1 stoichiometry, forming a complex of 311 aa. vCCI uses residues from its beta-sheet II to interact with a surface of MIP-1beta that includes residues adjacent to its N terminus, as well as residues in the 20's region and the 40's loop. This structure reveals the strategy used by vCCI to tightly bind numerous chemokines while retaining selectivity for the CC chemokine subfamily.

==About this Structure==

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[[Category: viral cc chemokine inhibitor]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:20:52 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Chemokines (chemotactic cytokines) comprise a large family of proteins, that recruit and activate leukocytes, giving chemokines a major role in, both immune response and inflammation-related diseases. The, poxvirus-encoded viral CC chemokine inhibitor (vCCI) binds to many CC, chemokines with high affinity, acting as a potent inhibitor of chemokine, action. We have used heteronuclear multidimensional NMR to determine the, structure of an orthopoxvirus vCCI in complex with a human CC chemokine, MIP-1beta (macrophage inflammatory protein 1beta). vCCI binds to the, chemokine with 1:1 stoichiometry, forming a complex of 311 aa. vCCI uses, residues from its beta-sheet II to interact with a surface of MIP-1beta, that includes residues adjacent to its N terminus, as well as residues in, the 20's region and the 40's loop. This structure reveals the strategy, used by vCCI to tightly bind numerous chemokines while retaining, selectivity for the CC chemokine subfamily.
+Chemokines (chemotactic cytokines) comprise a large family of proteins that recruit and activate leukocytes, giving chemokines a major role in both immune response and inflammation-related diseases. The poxvirus-encoded viral CC chemokine inhibitor (vCCI) binds to many CC chemokines with high affinity, acting as a potent inhibitor of chemokine action. We have used heteronuclear multidimensional NMR to determine the structure of an orthopoxvirus vCCI in complex with a human CC chemokine, MIP-1beta (macrophage inflammatory protein 1beta). vCCI binds to the chemokine with 1:1 stoichiometry, forming a complex of 311 aa. vCCI uses residues from its beta-sheet II to interact with a surface of MIP-1beta that includes residues adjacent to its N terminus, as well as residues in the 20's region and the 40's loop. This structure reveals the strategy used by vCCI to tightly bind numerous chemokines while retaining selectivity for the CC chemokine subfamily.
 ==About this Structure==
@@ Line 20: / Line 20: @@
 [[Category: viral cc chemokine inhibitor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:25:04 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:20:52 2008''