4be8: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===NEDD4 HECT A889F structure===

~~The entry 4be8~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/NEDD4_HUMAN NEDD4_HUMAN]] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2.<ref>PMID:17218260</ref> <ref>PMID:18562292</ref> <ref>PMID:20086093</ref> <ref>PMID:21765395</ref> <ref>PMID:21399620</ref>

~~Authors~~: ~~Maspero, E~~.~~, Valentini, E~~.~~, Mari, S~~.~~, Cecatiello, V~~.~~, Polo, S~~.~~, Pasqualato, S~~.

==About this Structure==

[[4be8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BE8 OCA].

~~Description~~: ~~NEDD4 HECT A889F structure~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Cecatiello, V.]]

[[Category: Mari, S.]]

[[Category: Maspero, E.]]

[[Category: Pasqualato, S.]]

[[Category: Polo, S.]]

[[Category: Valentini, E.]]

[[Category: Ligase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4be8|  PDB=4be8  |  SCENE=  }}
+===NEDD4 HECT A889F structure===
-The entry 4be8 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/NEDD4_HUMAN NEDD4_HUMAN]] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2.<ref>PMID:17218260</ref> <ref>PMID:18562292</ref> <ref>PMID:20086093</ref> <ref>PMID:21765395</ref> <ref>PMID:21399620</ref>
-Authors: Maspero, E., Valentini, E., Mari, S., Cecatiello, V., Polo, S., Pasqualato, S.
+==About this Structure==
+[[4be8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BE8 OCA].
-Description: NEDD4 HECT A889F structure
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Cecatiello, V.]]
+[[Category: Mari, S.]]
+[[Category: Maspero, E.]]
+[[Category: Pasqualato, S.]]
+[[Category: Polo, S.]]
+[[Category: Valentini, E.]]
+[[Category: Ligase]]