3p1a: Difference between revisions
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Revision as of 08:15, 2 May 2013
Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)
Function
[PMYT1_HUMAN] Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.[1] [2]
About this Structure
3p1a is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Liu F, Stanton JJ, Wu Z, Piwnica-Worms H. The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. Mol Cell Biol. 1997 Feb;17(2):571-83. PMID:9001210
- ↑ Liu F, Rothblum-Oviatt C, Ryan CE, Piwnica-Worms H. Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. Mol Cell Biol. 1999 Jul;19(7):5113-23. PMID:10373560
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Non-specific serine/threonine protein kinase
- Arrowsmith, C H.
- Berridge, G.
- Bountra, C.
- Chaikuad, A.
- Cooper, C D.O.
- Delft, F von.
- Edwards, A M.
- Eswaran, J.
- Fedorov, O.
- Knapp, S.
- Kroeler, T.
- Krojer, T.
- Muniz, J R.C.
- Pike, A C.W.
- SGC, Structural Genomics Consortium.
- Vollmar, M.
- Weigelt, J.
- Membrane-associated protein kinase
- Protein kinase
- Sgc
- Structural genomic
- Structural genomics consortium
- Transferase
- Tyrosine- and threonine-specific kinase
