3p71: Difference between revisions

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[[Image:3p71.jpg|left|200px]]
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The line below this paragraph, containing "STRUCTURE_3p71", creates the "Structure Box" on the page.
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{{STRUCTURE_3p71|  PDB=3p71  |  SCENE=  }}  
{{STRUCTURE_3p71|  PDB=3p71  |  SCENE=  }}  
===Crystal structure of the complex of LCMT-1 and PP2A===
===Crystal structure of the complex of LCMT-1 and PP2A===
{{ABSTRACT_PUBMED_21292165}}


 
==Function==
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[[http://www.uniprot.org/uniprot/LCMT1_HUMAN LCMT1_HUMAN]] Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.<ref>PMID:10600115</ref>  [[http://www.uniprot.org/uniprot/PP2AA_HUMAN PP2AA_HUMAN]] PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.<ref>PMID:9920888</ref> <ref>PMID:10801873</ref> <ref>PMID:22613722</ref> 
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{{ABSTRACT_PUBMED_21292165}}


==About this Structure==
==About this Structure==
[[3p71]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P71 OCA].  
[[3p71]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P71 OCA].  
==See Also==
*[[Protein phosphatase|Protein phosphatase]]


==Reference==
==Reference==
<ref group="xtra">PMID:21292165</ref><references group="xtra"/>
<ref group="xtra">PMID:021292165</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Phosphoprotein phosphatase]]
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[[Category: Stanevich, V.]]
[[Category: Stanevich, V.]]
[[Category: Xing, Y.]]
[[Category: Xing, Y.]]
[[Category: Leucine carboxymethyltransferase-1]]
[[Category: Methyltransferase]]
[[Category: S-adenosyl-l-methionine]]
[[Category: Serine/threonine protein keywds 2 phosphatase 2a]]
[[Category: Transferase-hydrolase complex]]
Retrieved from "https://proteopedia.org/3p71"