3obq: Difference between revisions
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{{STRUCTURE_3obq| PDB=3obq | SCENE= }} | {{STRUCTURE_3obq| PDB=3obq | SCENE= }} | ||
===Crystal Structure of the Tsg101 UEV domain in complex with a human HRS PSAP peptide=== | ===Crystal Structure of the Tsg101 UEV domain in complex with a human HRS PSAP peptide=== | ||
{{ABSTRACT_PUBMED_21070952}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TS101_HUMAN TS101_HUMAN]] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.<ref>PMID:11916981</ref> <ref>PMID:17853893</ref> <ref>PMID:17556548</ref> [[http://www.uniprot.org/uniprot/HGS_HUMAN HGS_HUMAN]] Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. | |||
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==About this Structure== | ==About this Structure== | ||
[[3obq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OBQ OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:021070952</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Hurley, J H.]] | [[Category: Hurley, J H.]] | ||
| Line 30: | Line 17: | ||
[[Category: Protein transprot]] | [[Category: Protein transprot]] | ||
[[Category: Ubiquitin binding]] | [[Category: Ubiquitin binding]] | ||
