3ohm: Difference between revisions
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{{STRUCTURE_3ohm| PDB=3ohm | SCENE= }} | {{STRUCTURE_3ohm| PDB=3ohm | SCENE= }} | ||
===Crystal structure of activated G alpha Q bound to its effector phospholipase C beta 3=== | ===Crystal structure of activated G alpha Q bound to its effector phospholipase C beta 3=== | ||
{{ABSTRACT_PUBMED_20966218}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GNAQ_MOUSE GNAQ_MOUSE]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro).<ref>PMID:17938235</ref> <ref>PMID:20624888</ref> [[http://www.uniprot.org/uniprot/PLCB3_HUMAN PLCB3_HUMAN]] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | |||
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==About this Structure== | ==About this Structure== | ||
[[3ohm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OHM OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020966218</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
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[[Category: Signaling protein - hydrolase complex]] | [[Category: Signaling protein - hydrolase complex]] | ||
[[Category: Tim barrel]] | [[Category: Tim barrel]] | ||