3olc: Difference between revisions

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[[Image:3olc.jpg|left|200px]]
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The line below this paragraph, containing "STRUCTURE_3olc", creates the "Structure Box" on the page.
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{{STRUCTURE_3olc|  PDB=3olc  |  SCENE=  }}  
{{STRUCTURE_3olc|  PDB=3olc  |  SCENE=  }}  
===Crystal structure of the N-terminal region of TopBP1===
===Crystal structure of the N-terminal region of TopBP1===
{{ABSTRACT_PUBMED_20858457}}


 
==Function==
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[[http://www.uniprot.org/uniprot/TOPB1_HUMAN TOPB1_HUMAN]] Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.<ref>PMID:10498869</ref> <ref>PMID:11395493</ref> <ref>PMID:11714696</ref> <ref>PMID:12697828</ref> <ref>PMID:15075294</ref> <ref>PMID:16530042</ref> 
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{{ABSTRACT_PUBMED_20858457}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:20858457</ref><references group="xtra"/>
<ref group="xtra">PMID:020858457</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bai, L.]]
[[Category: Bai, L.]]
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[[Category: Jiang, T.]]
[[Category: Jiang, T.]]
[[Category: Xu, M.]]
[[Category: Xu, M.]]
[[Category: Brct domain]]
[[Category: Dna binding protein]]
[[Category: Dna repair]]
[[Category: Rad9]]