3olc: Difference between revisions
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{{STRUCTURE_3olc| PDB=3olc | SCENE= }} | {{STRUCTURE_3olc| PDB=3olc | SCENE= }} | ||
===Crystal structure of the N-terminal region of TopBP1=== | ===Crystal structure of the N-terminal region of TopBP1=== | ||
{{ABSTRACT_PUBMED_20858457}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TOPB1_HUMAN TOPB1_HUMAN]] Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.<ref>PMID:10498869</ref> <ref>PMID:11395493</ref> <ref>PMID:11714696</ref> <ref>PMID:12697828</ref> <ref>PMID:15075294</ref> <ref>PMID:16530042</ref> | |||
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020858457</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bai, L.]] | [[Category: Bai, L.]] | ||
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[[Category: Jiang, T.]] | [[Category: Jiang, T.]] | ||
[[Category: Xu, M.]] | [[Category: Xu, M.]] | ||
[[Category: Brct domain]] | |||
[[Category: Dna binding protein]] | |||
[[Category: Dna repair]] | |||
[[Category: Rad9]] | |||