2foy: Difference between revisions
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New page: left|200px<br /> <applet load="2foy" size="450" color="white" frame="true" align="right" spinBox="true" caption="2foy, resolution 1.55Å" /> '''Human Carbonic Anhy... |
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[[Image:2foy.gif|left|200px]]<br /> | [[Image:2foy.gif|left|200px]]<br /><applet load="2foy" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2foy" size=" | |||
caption="2foy, resolution 1.55Å" /> | caption="2foy, resolution 1.55Å" /> | ||
'''Human Carbonic Anhydrase I complexed with a two-prong inhibitor'''<br /> | '''Human Carbonic Anhydrase I complexed with a two-prong inhibitor'''<br /> | ||
==Overview== | ==Overview== | ||
The atomic-resolution crystal structures of human carbonic anhydrases I | The atomic-resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors are reported. Each inhibitor contains a benzenesulfonamide prong and a cupric iminodiacetate (IDA-Cu(2+)) prong separated by linkers of different lengths and compositions. The ionized NH(-) group of each benzenesulfonamide coordinates to the active site Zn(2+) ion; the IDA-Cu(2+) prong of the tightest-binding inhibitor, BR30, binds to H64 of CAII and H200 of CAI. This work provides the first evidence verifying the structural basis of nanomolar affinity measured for two-prong inhibitors targeting the carbonic anhydrases. | ||
==About this Structure== | ==About this Structure== | ||
2FOY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN and B30 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] Full crystallographic information is available from [http:// | 2FOY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=B30:'>B30</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FOY OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Banerjee, A | [[Category: Banerjee, A L.]] | ||
[[Category: Christianson, D | [[Category: Christianson, D W.]] | ||
[[Category: Haldar, M | [[Category: Haldar, M K.]] | ||
[[Category: Jude, K | [[Category: Jude, K M.]] | ||
[[Category: Mallik, S.]] | [[Category: Mallik, S.]] | ||
[[Category: Manokaran, S.]] | [[Category: Manokaran, S.]] | ||
[[Category: Roy, B.]] | [[Category: Roy, B.]] | ||
[[Category: Srivastava, D | [[Category: Srivastava, D K.]] | ||
[[Category: B30]] | [[Category: B30]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:23:41 2008'' | ||
