2fp7: Difference between revisions
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New page: left|200px<br /><applet load="2fp7" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fp7, resolution 1.68Å" /> '''West Nile Virus NS2B... |
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[[Image:2fp7.gif|left|200px]]<br /><applet load="2fp7" size=" | [[Image:2fp7.gif|left|200px]]<br /><applet load="2fp7" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2fp7, resolution 1.68Å" /> | caption="2fp7, resolution 1.68Å" /> | ||
'''West Nile Virus NS2B/NS3protease in complex with Bz-Nle-Lys-Arg-Arg-H'''<br /> | '''West Nile Virus NS2B/NS3protease in complex with Bz-Nle-Lys-Arg-Arg-H'''<br /> | ||
==Overview== | ==Overview== | ||
The replication of flaviviruses requires the correct processing of their | The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation. | ||
==About this Structure== | ==About this Structure== | ||
2FP7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/West_nile_virus West nile virus] with NDL as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Flavivirin Flavivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.91 3.4.21.91] Full crystallographic information is available from [http:// | 2FP7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/West_nile_virus West nile virus] with <scene name='pdbligand=NDL:'>NDL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Flavivirin Flavivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.91 3.4.21.91] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FP7 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: West nile virus]] | [[Category: West nile virus]] | ||
[[Category: Arcy, A | [[Category: Arcy, A D.]] | ||
[[Category: Erbel, P.]] | [[Category: Erbel, P.]] | ||
[[Category: Schiering, N.]] | [[Category: Schiering, N.]] | ||
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[[Category: substrate-based inhibitor]] | [[Category: substrate-based inhibitor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:23:41 2008'' | ||
