3oz1: Difference between revisions

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{{Seed}}
[[Image:3oz1.jpg|left|200px]]
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{{STRUCTURE_3oz1|  PDB=3oz1  |  SCENE=  }}  
{{STRUCTURE_3oz1|  PDB=3oz1  |  SCENE=  }}  
===cIAP1-BIR3 domain in complex with the Smac-mimetic compound Smac066===
===cIAP1-BIR3 domain in complex with the Smac-mimetic compound Smac066===
{{ABSTRACT_PUBMED_20954235}}


 
==Function==
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[[http://www.uniprot.org/uniprot/BIRC2_HUMAN BIRC2_HUMAN]] Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.<ref>PMID:15665297</ref> <ref>PMID:18082613</ref> <ref>PMID:21145488</ref> <ref>PMID:21653699</ref> <ref>PMID:21931591</ref> 
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{{ABSTRACT_PUBMED_20954235}}


==About this Structure==
==About this Structure==
3OZ1 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OZ1 OCA].  
[[3oz1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OZ1 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20954235</ref><references group="xtra"/>
<ref group="xtra">PMID:020954235</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bolognesi, M.]]
[[Category: Bolognesi, M.]]
Line 34: Line 21:
[[Category: Caspase]]
[[Category: Caspase]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 14:19:04 2010''
Retrieved from "https://proteopedia.org/3oz1"