3osl: Difference between revisions

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[[Image:3osl.png|left|200px]]
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The line below this paragraph, containing "STRUCTURE_3osl", creates the "Structure Box" on the page.
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{{STRUCTURE_3osl|  PDB=3osl  |  SCENE=  }}  
{{STRUCTURE_3osl|  PDB=3osl  |  SCENE=  }}  
===Structure of bovine thrombin-activatable fibrinolysis inhibitor in complex with tick carboxypeptidase inhibitor===
===Structure of bovine thrombin-activatable fibrinolysis inhibitor in complex with tick carboxypeptidase inhibitor===
{{ABSTRACT_PUBMED_20880845}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/CBPB2_BOVIN CBPB2_BOVIN]] Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
The line below this paragraph, {{ABSTRACT_PUBMED_20880845}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_20880845}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:20880845</ref><ref group="xtra">PMID:20088943</ref><ref group="xtra">PMID:18722183</ref><references group="xtra"/>
<ref group="xtra">PMID:020880845</ref><ref group="xtra">PMID:020088943</ref><ref group="xtra">PMID:018722183</ref><references group="xtra"/><references/>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Carboxypeptidase U]]
[[Category: Carboxypeptidase U]]

Revision as of 08:37, 2 May 2013

Template:STRUCTURE 3osl

Structure of bovine thrombin-activatable fibrinolysis inhibitor in complex with tick carboxypeptidase inhibitor

Template:ABSTRACT PUBMED 20880845

Function

[CBPB2_BOVIN] Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.

About this Structure

3osl is a 4 chain structure with sequence from Bos taurus and Rhipicephalus bursa. Full crystallographic information is available from OCA.

Reference

  1. Valnickova Z, Sanglas L, Arolas JL, Petersen SV, Schar C, Otzen D, Aviles FX, Gomis-Ruth FX, Enghild JJ. Flexibility of the thrombin-activatable fibrinolysis inhibitor pro-domain enables productive binding of protein substrates. J Biol Chem. 2010 Dec 3;285(49):38243-50. Epub 2010 Sep 29. PMID:20880845 doi:10.1074/jbc.M110.150342
  2. Sanglas L, Arolas JL, Valnickova Z, Aviles FX, Enghild JJ, Gomis-Ruth FX. Insights into the molecular inactivation mechanism of human activated thrombin-activatable fibrinolysis inhibitor. J Thromb Haemost. 2010 May;8(5):1056-65. Epub 2010 Jan 17. PMID:20088943 doi:10.1111/j.1538-7836.2010.03740.x
  3. Sanglas L, Valnickova Z, Arolas JL, Pallares I, Guevara T, Sola M, Kristensen T, Enghild JJ, Aviles FX, Gomis-Ruth FX. Structure of activated thrombin-activatable fibrinolysis inhibitor, a molecular link between coagulation and fibrinolysis. Mol Cell. 2008 Aug 22;31(4):598-606. PMID:18722183 doi:10.1016/j.molcel.2008.05.031

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