Complement Regulator-Acquiring Surface Protein: Difference between revisions
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=== '''Host Immune Response Evasion''' === | === '''Host Immune Response Evasion''' === | ||
BbCRASP-1 has an affinity for Factor H (a regulatory protein secreted by the complement immune system) and Factor H-like proteins. Therefore, Factor H binds to BbCRASP-1, which is bound to the outer surface of the spirochete. Because there are multiple BbCRASP-1 proteins on the spirochete, the spirochete is coated with | BbCRASP-1 has an affinity for [http://www.uniprot.org/uniprot/CFAH_HUMAN Factor H] (a regulatory protein secreted by the [http://en.wikipedia.org/wiki/Complement_system complement immune system) and Factor H-like proteins. Therefore, Factor H binds to BbCRASP-1, which is bound to the outer surface of the spirochete. Because there are multiple BbCRASP-1 proteins on the spirochete, the spirochete is coated with Factor H and effectively able to infiltrate the host and go undetected in the host's plasma<ref name="Bykowski">PMID: 17562769</ref>. | ||
=== '''Relation to the Extra Cellular Matrix''' === | === '''Relation to the Extra Cellular Matrix''' === | ||
