4iw5: Difference between revisions
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{{STRUCTURE_4iw5| PDB=4iw5 | SCENE= }} | {{STRUCTURE_4iw5| PDB=4iw5 | SCENE= }} | ||
===Thymidylate synthase ternary complex with dUMP and CB3717=== | ===Thymidylate synthase ternary complex with dUMP and CB3717=== | ||
{{ABSTRACT_PUBMED_23611499}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI]] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation. | |||
==About this Structure== | ==About this Structure== | ||
| Line 11: | Line 10: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:016768437</ref><references group="xtra"/> | <ref group="xtra">PMID:016768437</ref><references group="xtra"/><references/> | ||
[[Category: Escherichia coli k-12]] | [[Category: Escherichia coli k-12]] | ||
[[Category: Thymidylate synthase]] | [[Category: Thymidylate synthase]] | ||
Revision as of 06:40, 8 May 2013
Thymidylate synthase ternary complex with dUMP and CB3717
Template:ABSTRACT PUBMED 23611499
Function
[TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
About this Structure
4iw5 is a 2 chain structure with sequence from Escherichia coli k-12. This structure supersedes the now removed PDB entry 2g8o. Full crystallographic information is available from OCA.
Reference
- Newby Z, Lee TT, Morse RJ, Liu Y, Liu L, Venkatraman P, Santi DV, Finer-Moore JS, Stroud RM. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20;45(24):7415-28. PMID:16768437 doi:10.1021/bi060152s
