4jc5: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Immune activator bound to receptor===

~~The entry 4jc5~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/STING_MOUSE STING_MOUSE]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18559423</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:23258412</ref>

~~Authors~~: ~~Deimling, T~~.~~, Hopfner, K~~.P.

==About this Structure==

[[4jc5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JC5 OCA].

~~Description~~: Immune ~~activator bound to~~ receptor

==Reference==

[[Category: Mus musculus]]

[[Category: Deimling, T.]]

[[Category: Hopfner, K P.]]

[[Category: Immune system]]

[[Category: Innate immune receptor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jc5|  PDB=4jc5  |  SCENE=  }}
+===Immune activator bound to receptor===
+{{ABSTRACT_PUBMED_23604073}}
-The entry 4jc5 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/STING_MOUSE STING_MOUSE]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18559423</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:23258412</ref>
-Authors: Deimling, T., Hopfner, K.P.
+==About this Structure==
+[[4jc5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JC5 OCA].
-Description: Immune activator bound to receptor
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Mus musculus]]
+[[Category: Deimling, T.]]
+[[Category: Hopfner, K P.]]
+[[Category: Immune system]]
+[[Category: Innate immune receptor]]