4bik: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of a disulfide locked mutant of Intermedilysin with human CD59===

~~The~~ entry ~~4bik is ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:[http://omim.org/entry/612300 612300]].<ref>PMID:1382994</ref>

~~Authors~~: ~~Johnson, S~~.~~, Brooks, N~~.J., ~~Smith, R~~.A.G., ~~Lea, S.M., Bubeck, D~~.

==Function==

[[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.

~~Description:~~ Structure of a ~~disulfide locked mutant of Intermedilysin~~ with ~~human CD59~~

==About this Structure==

[[4bik]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Streptococcus_intermedius Streptococcus intermedius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIK OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Streptococcus intermedius]]

[[Category: Brooks, N J.]]

[[Category: Bubeck, D.]]

[[Category: Johnson, S.]]

[[Category: Lea, S M.]]

[[Category: Smith, R A.G.]]

[[Category: Cholesterol dependent cytotoxin]]

[[Category: Complement]]

[[Category: Immune system]]

[[Category: Membrane attack complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4bik|  PDB=4bik  |  SCENE=  }}
+===Structure of a disulfide locked mutant of Intermedilysin with human CD59===
-The entry 4bik is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:[http://omim.org/entry/612300 612300]].<ref>PMID:1382994</ref>
-Authors: Johnson, S., Brooks, N.J., Smith, R.A.G., Lea, S.M., Bubeck, D.
+==Function==
+[[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.  The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
-Description: Structure of a disulfide locked mutant of Intermedilysin with human CD59
+==About this Structure==
+[[4bik]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Streptococcus_intermedius Streptococcus intermedius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIK OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Streptococcus intermedius]]
+[[Category: Brooks, N J.]]
+[[Category: Bubeck, D.]]
+[[Category: Johnson, S.]]
+[[Category: Lea, S M.]]
+[[Category: Smith, R A.G.]]
+[[Category: Cholesterol dependent cytotoxin]]
+[[Category: Complement]]
+[[Category: Immune system]]
+[[Category: Membrane attack complex]]