2g9c: Difference between revisions
New page: left|200px<br /><applet load="2g9c" size="350" color="white" frame="true" align="right" spinBox="true" caption="2g9c, resolution 1.70Å" /> '''Modified pyrimidines... |
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Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17076468 17076468] | Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17076468 17076468] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Batey, R | [[Category: Batey, R T.]] | ||
[[Category: Gilbert, S | [[Category: Gilbert, S D.]] | ||
[[Category: Mediatore, S | [[Category: Mediatore, S J.]] | ||
[[Category: 3AY]] | [[Category: 3AY]] | ||
[[Category: ACT]] | [[Category: ACT]] | ||
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[[Category: triaminopyrimidine]] | [[Category: triaminopyrimidine]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:29:25 2008'' | ||
Revision as of 15:29, 21 February 2008
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Modified pyrimidines Specifically bind the purine riboswitch
Overview
The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized.
About this Structure
2G9C is a Protein complex structure of sequences from [1] with ACT, NCO and 3AY as ligands. Full crystallographic information is available from OCA.
Reference
Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:17076468
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