4jr0: Difference between revisions
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{{STRUCTURE_4jr0| PDB=4jr0 | SCENE= }} | |||
===Human procaspase-3 bound to Ac-DEVD-CMK=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref> | |||
==About this Structure== | |||
[[4jr0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JR0 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Caspase-3]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Thomsen, N D.]] | |||
[[Category: Wells, J A.]] | |||
[[Category: Activity based probe]] | |||
[[Category: Apoptosis]] | |||
[[Category: Caspase]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Irreversible inhibitor]] | |||
[[Category: Proenzyme]] | |||
[[Category: Protease]] | |||
[[Category: Protein-peptide complex]] | |||
Revision as of 07:56, 8 May 2013
Human procaspase-3 bound to Ac-DEVD-CMK
Function
[CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.[1] [2]
About this Structure
4jr0 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, et al.. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 1995 Jul 6;376(6535):37-43. PMID:7596430 doi:https://dx.doi.org/10.1038/376037a0
- ↑ Cabrera JR, Bouzas-Rodriguez J, Tauszig-Delamasure S, Mehlen P. RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons. J Biol Chem. 2011 Apr 22;286(16):14628-38. doi: 10.1074/jbc.M110.195461. Epub, 2011 Feb 28. PMID:21357690 doi:10.1074/jbc.M110.195461
