3pkm: Difference between revisions
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{{STRUCTURE_3pkm| PDB=3pkm | SCENE= }} | {{STRUCTURE_3pkm| PDB=3pkm | SCENE= }} | ||
===Crystal structure of Cas6 with its substrate RNA=== | ===Crystal structure of Cas6 with its substrate RNA=== | ||
{{ABSTRACT_PUBMED_21300293}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/Q8U1S4_PYRFU Q8U1S4_PYRFU]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), also called psiRNA (prokaryotic silencing) in this organism. Processes pre-crRNA into individual crRNA units, with an 8-nt 5'-repeat DNA tag that may help other proteins recognize the crRNA. Further processing occurs at their 3' termini in this organism. Generates a 5' hydroxy and 2',3'-cyclic phosphodiester.<ref>PMID:20884784</ref> <ref>PMID:19141480</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:021300293</ref><references group="xtra"/><references/> | ||
[[Category: Pyrococcus furiosus]] | [[Category: Pyrococcus furiosus]] | ||
[[Category: Li, H.]] | [[Category: Li, H.]] | ||
[[Category: Preamplume, G.]] | [[Category: Preamplume, G.]] | ||
[[Category: Wang, R.]] | [[Category: Wang, R.]] | ||
[[Category: Cas6]] | |||
[[Category: Crispr]] | |||
[[Category: Crispr processing endonuclease]] | |||
[[Category: Endonuclease]] | |||
[[Category: Ferridoxin fold]] | |||
[[Category: Hydrolase-rna complex]] | |||
[[Category: Repeat rna]] | |||