3pnl: Difference between revisions
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{{STRUCTURE_3pnl| PDB=3pnl | SCENE= }} | {{STRUCTURE_3pnl| PDB=3pnl | SCENE= }} | ||
===Crystal Structure of E.coli Dha kinase DhaK-DhaL complex=== | ===Crystal Structure of E.coli Dha kinase DhaK-DhaL complex=== | ||
{{ABSTRACT_PUBMED_21209328}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DHAK_ECOLI DHAK_ECOLI]] Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. Binds covalently dihydroxyacetone in hemiaminal linkage. Acts also as a corepressor of DhaR by binding to its sensor domain, in the absence of dihydroxyacetone. [[http://www.uniprot.org/uniprot/DHAL_ECOLI DHAL_ECOLI]] ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. DhaL-ADP receives a phosphoryl group from DhaM and transmits it to dihydroxyacetone. DhaL-ADP acts also as a coactivator by binding to the sensor domain of DhaR. DhaL-ATP is inactive. | |||
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==About this Structure== | ==About this Structure== | ||
[[3pnl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli | [[3pnl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PNL OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:021209328</ref><references group="xtra"/><references/> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]] | [[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]] | ||
[[Category: Cygler, M.]] | [[Category: Cygler, M.]] | ||
| Line 31: | Line 18: | ||
[[Category: McDonald, L.]] | [[Category: McDonald, L.]] | ||
[[Category: Shi, R.]] | [[Category: Shi, R.]] | ||
[[Category: Bsgi]] | |||
[[Category: Dha kinase]] | |||
[[Category: Montreal-kingston bacterial structural genomics initiative]] | |||
[[Category: Structural genomic]] | |||
[[Category: Transferase]] | |||
Revision as of 08:17, 8 May 2013
Crystal Structure of E.coli Dha kinase DhaK-DhaL complex
Template:ABSTRACT PUBMED 21209328
Function
[DHAK_ECOLI] Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. Binds covalently dihydroxyacetone in hemiaminal linkage. Acts also as a corepressor of DhaR by binding to its sensor domain, in the absence of dihydroxyacetone. [DHAL_ECOLI] ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. DhaL-ADP receives a phosphoryl group from DhaM and transmits it to dihydroxyacetone. DhaL-ADP acts also as a coactivator by binding to the sensor domain of DhaR. DhaL-ATP is inactive.
About this Structure
3pnl is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
- Shi R, McDonald L, Cui Q, Matte A, Cygler M, Ekiel I. Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase. Proc Natl Acad Sci U S A. 2011 Jan 5. PMID:21209328 doi:10.1073/pnas.1012596108
