2gcu: Difference between revisions
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New page: left|200px<br /><applet load="2gcu" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gcu, resolution 1.477Å" /> '''X-Ray Structure of ... |
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[[Image:2gcu.gif|left|200px]]<br /><applet load="2gcu" size=" | [[Image:2gcu.gif|left|200px]]<br /><applet load="2gcu" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2gcu, resolution 1.477Å" /> | caption="2gcu, resolution 1.477Å" /> | ||
'''X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580'''<br /> | '''X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580'''<br /> | ||
==Overview== | ==Overview== | ||
The protein product of gene At1g53580 from Arabidopsis thaliana possesses | The protein product of gene At1g53580 from Arabidopsis thaliana possesses 54% sequence identity to a human enzyme that has been implicated in the rare disorder ethylmalonic encephalopathy. The structure of the At1g53580 protein has been solved to a nominal resolution of 1.48 Angstrom. This structure reveals tertiary structure differences between the ETHE1-like enzyme and glyoxalase II enzymes that are likely to account for differences in reaction chemistry and multimeric state between the two types of enzymes. In addition, the Arabidopsis ETHE1 protein is used as a model to explain the significance of several mutations in the human enzyme that have been observed in patients with ethylmalonic encephalopathy. | ||
==About this Structure== | ==About this Structure== | ||
2GCU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with FE2, SO4 and EDO as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Hydroxyacylglutathione_hydrolase Hydroxyacylglutathione hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.6 3.1.2.6] Full crystallographic information is available from [http:// | 2GCU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with <scene name='pdbligand=FE2:'>FE2</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Hydroxyacylglutathione_hydrolase Hydroxyacylglutathione hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.6 3.1.2.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCU OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Hydroxyacylglutathione hydrolase]] | [[Category: Hydroxyacylglutathione hydrolase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bingman, C | [[Category: Bingman, C A.]] | ||
[[Category: Bitto, E.]] | [[Category: Bitto, E.]] | ||
[[Category: CESG, Center | [[Category: CESG, Center for Eukaryotic Structural Genomics.]] | ||
[[Category: Jr., G | [[Category: Jr., G N.Phillips.]] | ||
[[Category: McCoy, J | [[Category: McCoy, J G.]] | ||
[[Category: Wesenberg, G | [[Category: Wesenberg, G E.]] | ||
[[Category: EDO]] | [[Category: EDO]] | ||
[[Category: FE2]] | [[Category: FE2]] | ||
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[[Category: structural genomics]] | [[Category: structural genomics]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:30:26 2008'' | ||
