2xhl: Difference between revisions
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m Protected "2xhl" [edit=sysop:move=sysop] |
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{{STRUCTURE_2xhl| PDB=2xhl | SCENE= }} | {{STRUCTURE_2xhl| PDB=2xhl | SCENE= }} | ||
===STRUCTURE OF A FUNCTIONAL DERIVATIVE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN TYPE B=== | ===STRUCTURE OF A FUNCTIONAL DERIVATIVE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN TYPE B=== | ||
{{ABSTRACT_PUBMED_21078393}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | |||
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021078393</ref><references group="xtra"/> | <ref group="xtra">PMID:021078393</ref><references group="xtra"/><references/> | ||
[[Category: Bontoxilysin]] | [[Category: Bontoxilysin]] | ||
[[Category: Clostridium botulinum]] | [[Category: Clostridium botulinum]] | ||