2kzy: Difference between revisions
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{{STRUCTURE_2kzy| PDB=2kzy | SCENE= }} | {{STRUCTURE_2kzy| PDB=2kzy | SCENE= }} | ||
===Solution NMR structure of the ZNF216 A20 zinc finger=== | ===Solution NMR structure of the ZNF216 A20 zinc finger=== | ||
{{ABSTRACT_PUBMED_021923101}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/B5DF11_RAT B5DF11_RAT]] Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
Revision as of 08:27, 8 May 2013
Solution NMR structure of the ZNF216 A20 zinc finger
Template:ABSTRACT PUBMED 021923101
Function
[B5DF11_RAT] Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation (By similarity).
About this Structure
2kzy is a 1 chain structure with sequence from Rattus norvegicus. Full experimental information is available from OCA.
