3dls: Difference between revisions

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[[Image:3dls.png|left|200px]]
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The line below this paragraph, containing "STRUCTURE_3dls", creates the "Structure Box" on the page.
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{{STRUCTURE_3dls|  PDB=3dls  |  SCENE=  }}  
{{STRUCTURE_3dls|  PDB=3dls  |  SCENE=  }}  
===Crystal structure of human PAS kinase bound to ADP===
===Crystal structure of human PAS kinase bound to ADP===
{{ABSTRACT_PUBMED_20943661}}


 
==Function==
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[[http://www.uniprot.org/uniprot/PASK_HUMAN PASK_HUMAN]] Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.<ref>PMID:16275910</ref> <ref>PMID:17052199</ref> <ref>PMID:17595531</ref> <ref>PMID:21181396</ref> <ref>PMID:21418524</ref> <ref>PMID:20943661</ref>
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{{ABSTRACT_PUBMED_20943661}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:020943661</ref><references group="xtra"/>
<ref group="xtra">PMID:020943661</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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