SB2013 L08gr01: Difference between revisions
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[[Image:Electronegativity of OspC.jpg]] | [[Image:Electronegativity of OspC.jpg]] | ||
In this image, elctrostatic potential surface of HB19 (A)(invasive group) and 212 (B)(non-invasive group) is shown. Red region in the HB19 is the highly negative region across the two fold axis in invasive species of OspC. | |||
==Structural Function== | ==Structural Function== | ||
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==Super Vaccination== | ==Super Vaccination== | ||
Since OspC helps with early transmission of spirochete to the host body, it will be much more efficient to develop a vaccine based on OspC compared to the current vaccination based on OspA (Kumaran et al. 2001). In addition, a combinatory vaccination based on both OspA and OspC may be developed to not only produce antibody in the host body responding to OspC but also disinfecting the tick while it feeds on the host blood containing antibodies for OspA (Greenberg 2001). Nevertheless, due to high variance in structure (within invasive groups, which can even vary depending on location), it is a matter of difficulty to produce a globalized vaccination (Kumaran et al. 2001). A globalized vaccination may work by denaturing the structure of OspC and making it impossible for it to bind is to host cells. A proposed target area for a vaccine may include areas like the well-conserved immunodominant epitope present at the carboxy-terminal of OspC (Jobe et. al 2003). | Since OspC helps with early transmission of spirochete to the host body, it will be much more efficient to develop a vaccine based on OspC compared to the current vaccination based on OspA (Kumaran et al. 2001). In addition, a combinatory vaccination based on both OspA and OspC may be developed to not only produce antibody in the host body responding to OspC but also disinfecting the tick while it feeds on the host blood containing antibodies for OspA (Greenberg 2001). Nevertheless, due to high variance in structure (within invasive groups, which can even vary depending on location), it is a matter of difficulty to produce a globalized vaccination (Kumaran et al. 2001). A globalized vaccination may work by denaturing the structure of OspC and making it impossible for it to bind is to host cells. A proposed target area for a vaccine may include areas like the well-conserved immunodominant epitope present at the carboxy-terminal of OspC (Jobe et. al 2003). | ||
== References == | |||
1. | |||
