SB2013 L04gr5: Difference between revisions
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<scene name='SB2013_L04gr5/Reset_original/2'>Reset Structure</scene> | <scene name='SB2013_L04gr5/Reset_original/2'>Reset Structure</scene> | ||
=VlsE as a Diagnostic Tool= | |||
== IR 6== | |||
IR6 is instrumental in the serodiagnosis of Lyme disease in its early stages. The sensitivity and precision of ELISA was measured based on a 26-mer synthetic peptide (C6) whose sequence matched that of IR6 (Marangoni et al 2006). Serum samples in nonhuman primates that were introduced to different strains of B. burgdorferi were assessed for antibody responses. Antibody IgG was present in high levels for all animals over a 160-week period following infection. Human patients assessed with the C6 ELISA yielded 74% detection sensitivity in the acute disease type, 90% in the convalescent (recovery) phase, 95% in the early disseminated phase, and 100% in late Lyme disease. | |||
=References= | =References= | ||
