SB2013 L04gr5: Difference between revisions
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=Invariable Regions= | =Invariable Regions= | ||
<Structure load='1L8W' size=' | <Structure load='1L8W' size='350' frame='true' align='right' caption='VlsE' scene='Insert optional scene name here' /> | ||
Interspersed in the variable regions of the variable domain are six invariable regions (IR1-IR6). Although located on the membrane distal region of the protein, the IRs are buried within the protein and have little exposure to the surface. The IRs might be further hidden from surface exposure due to the possible dimerization of VlsE, forming a shield at the monomer-monomer interface (Eicken et al 2002). These six IRs do not undergo changes during antigenic variation and are present in many strains and genospecies of B. burgdorferi. | Interspersed in the variable regions of the variable domain are six invariable regions (IR1-IR6). Although located on the membrane distal region of the protein, the IRs are buried within the protein and have little exposure to the surface. The IRs might be further hidden from surface exposure due to the possible dimerization of VlsE, forming a shield at the monomer-monomer interface (Eicken et al 2002). These six IRs do not undergo changes during antigenic variation and are present in many strains and genospecies of B. burgdorferi. | ||
