2gic: Difference between revisions

Line 1:

[[Image:2gic.gif|left|200px]]<br /><applet load="2gic" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:2gic.gif|left|200px]]<br /><applet load="2gic" size="350" color="white" frame="true" align="right" spinBox="true"

caption="2gic, resolution 2.920Å" />

'''Crystal Structure of a vesicular stomatitis virus nucleocapsid-RNA complex'''<br />

==Overview==

Vesicular stomatitis virus is a negative-stranded RNA virus. Its, nucleoprotein (N) binds the viral genomic RNA and is involved in multiple, functions including transcription, replication, and assembly. We have, determined a 2.9 angstrom structure of a complex containing 10 molecules, of the N protein and 90 bases of RNA. The RNA is tightly sequestered in a, cavity at the interface between two lobes of the N protein. This serves to, protect the RNA in the absence of polynucleotide synthesis. For the RNA to, be accessed, some conformational change in the N protein should be, necessary.

Vesicular stomatitis virus is a negative-stranded RNA virus. Its nucleoprotein (N) binds the viral genomic RNA and is involved in multiple functions including transcription, replication, and assembly. We have determined a 2.9 angstrom structure of a complex containing 10 molecules of the N protein and 90 bases of RNA. The RNA is tightly sequestered in a cavity at the interface between two lobes of the N protein. This serves to protect the RNA in the absence of polynucleotide synthesis. For the RNA to be accessed, some conformational change in the N protein should be necessary.

==About this Structure==

2GIC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus] with IUM as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2GIC OCA].

2GIC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus] with <scene name='pdbligand=IUM:'>IUM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIC OCA].

==Reference==

Line 13:

[[Category: Single protein]]

[[Category: Vesicular stomatitis indiana virus]]

[[Category: Green, T.J.]]

[[Category: Green, T J.]]

[[Category: Luo, M.]]

[[Category: Wertz, G.W.]]

[[Category: Wertz, G W.]]

[[Category: Zhang, X.]]

[[Category: IUM]]

Line 22:

[[Category: protein-rna complex]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 11:13:~~04 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:31:57 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:2gic.gif|left|200px]]<br /><applet load="2gic" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:2gic.gif|left|200px]]<br /><applet load="2gic" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="2gic, resolution 2.920&Aring;" />
 '''Crystal Structure of a vesicular stomatitis virus nucleocapsid-RNA complex'''<br />
 ==Overview==
-Vesicular stomatitis virus is a negative-stranded RNA virus. Its, nucleoprotein (N) binds the viral genomic RNA and is involved in multiple, functions including transcription, replication, and assembly. We have, determined a 2.9 angstrom structure of a complex containing 10 molecules, of the N protein and 90 bases of RNA. The RNA is tightly sequestered in a, cavity at the interface between two lobes of the N protein. This serves to, protect the RNA in the absence of polynucleotide synthesis. For the RNA to, be accessed, some conformational change in the N protein should be, necessary.
+Vesicular stomatitis virus is a negative-stranded RNA virus. Its nucleoprotein (N) binds the viral genomic RNA and is involved in multiple functions including transcription, replication, and assembly. We have determined a 2.9 angstrom structure of a complex containing 10 molecules of the N protein and 90 bases of RNA. The RNA is tightly sequestered in a cavity at the interface between two lobes of the N protein. This serves to protect the RNA in the absence of polynucleotide synthesis. For the RNA to be accessed, some conformational change in the N protein should be necessary.
 ==About this Structure==
-GIC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus] with IUM as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2GIC OCA].
+GIC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus] with <scene name='pdbligand=IUM:'>IUM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIC OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Single protein]]
 [[Category: Vesicular stomatitis indiana virus]]
-[[Category: Green, T.J.]]
+[[Category: Green, T J.]]
 [[Category: Luo, M.]]
-[[Category: Wertz, G.W.]]
+[[Category: Wertz, G W.]]
 [[Category: Zhang, X.]]
 [[Category: IUM]]
@@ Line 22: / Line 22: @@
 [[Category: protein-rna complex]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 11:13:04 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:31:57 2008''