3znn: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3znn| PDB=3znn | SCENE= }} | |||
===IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN=== | |||
{{ABSTRACT_PUBMED_23631755}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref> | |||
==About this Structure== | |||
[[3znn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNN OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: D-amino-acid oxidase]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Allen, M S.]] | |||
[[Category: Bowen, C A.]] | |||
[[Category: Chytil, M.]] | |||
[[Category: Fang, Q K.]] | |||
[[Category: Foglesong, R J.]] | |||
[[Category: Hardy, L W.]] | |||
[[Category: Heffernan, M L.R.]] | |||
[[Category: Hopkins, S C.]] | |||
[[Category: Jones, S W.]] | |||
[[Category: Koch, P.]] | |||
[[Category: Large, T H.]] | |||
[[Category: Melnick, L.]] | |||
[[Category: Molla, G.]] | |||
[[Category: Nardini, M.]] | |||
[[Category: Oliet, S H.R.]] | |||
[[Category: Orsini, M A.]] | |||
[[Category: Panatier, A.]] | |||
[[Category: Piubelli, L.]] | |||
[[Category: Pollegioni, L.]] | |||
[[Category: Saraswat, L D.]] | |||
[[Category: Soukri, M.]] | |||
[[Category: Spear, K L.]] | |||
[[Category: Varney, M A.]] | |||
[[Category: Flavooxidase]] | |||
[[Category: Neurotransmission]] | |||
[[Category: Oxidoreductase]] | |||
Revision as of 07:19, 16 May 2013
IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN
Template:ABSTRACT PUBMED 23631755
Function
[OXDA_HUMAN] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.[1]
About this Structure
3znn is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Kawazoe T, Tsuge H, Imagawa T, Aki K, Kuramitsu S, Fukui K. Structural basis of D-DOPA oxidation by D-amino acid oxidase: alternative pathway for dopamine biosynthesis. Biochem Biophys Res Commun. 2007 Apr 6;355(2):385-91. Epub 2007 Feb 8. PMID:17303072 doi:10.1016/j.bbrc.2007.01.181
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- D-amino-acid oxidase
- Homo sapiens
- Allen, M S.
- Bowen, C A.
- Chytil, M.
- Fang, Q K.
- Foglesong, R J.
- Hardy, L W.
- Heffernan, M L.R.
- Hopkins, S C.
- Jones, S W.
- Koch, P.
- Large, T H.
- Melnick, L.
- Molla, G.
- Nardini, M.
- Oliet, S H.R.
- Orsini, M A.
- Panatier, A.
- Piubelli, L.
- Pollegioni, L.
- Saraswat, L D.
- Soukri, M.
- Spear, K L.
- Varney, M A.
- Flavooxidase
- Neurotransmission
- Oxidoreductase
