2gop: Difference between revisions

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==Overview==

In the proteolytic pathway of prokaryotic and eukaryotic organisms, proteins tagged for proteolysis are firstly shredded into smaller peptides, by compartmentalized proteases such as the proteasome complex., Accordingly, a variety of downstream proteases have evolved to further, hydrolyze these peptides to the level of free amino acids. In the search, for such downstream proteases, a high-molecular-weight protease complex, called trilobed protease (TLP) was recently discovered in the archaeon, Pyroccocus furiosus. The crystal structure of the N-terminal, beta-propeller domain of the trilobed protease at 2 A resolution shows, that the trilobed protease utilizes this accessory domain to control, substrate access to the active site. Modelling of the intact TLP monomer, suggests that this protease has an additional side entrance to its active, site as in the DPP-IV or tricorn protease complexes.

In the proteolytic pathway of prokaryotic and eukaryotic organisms, proteins tagged for proteolysis are firstly shredded into smaller peptides by compartmentalized proteases such as the proteasome complex. Accordingly, a variety of downstream proteases have evolved to further hydrolyze these peptides to the level of free amino acids. In the search for such downstream proteases, a high-molecular-weight protease complex called trilobed protease (TLP) was recently discovered in the archaeon Pyroccocus furiosus. The crystal structure of the N-terminal beta-propeller domain of the trilobed protease at 2 A resolution shows that the trilobed protease utilizes this accessory domain to control substrate access to the active site. Modelling of the intact TLP monomer suggests that this protease has an additional side entrance to its active site as in the DPP-IV or tricorn protease complexes.

==About this Structure==

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[[Category: Baumeister, W.]]

[[Category: Bosch, J.]]

[[Category: Essen, L.O.]]

[[Category: Essen, L O.]]

[[Category: Tamura, N.]]

[[Category: Tamura, T.]]

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[[Category: open velcro]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jan 29 20~~:04:42 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:33:47 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-In the proteolytic pathway of prokaryotic and eukaryotic organisms, proteins tagged for proteolysis are firstly shredded into smaller peptides, by compartmentalized proteases such as the proteasome complex., Accordingly, a variety of downstream proteases have evolved to further, hydrolyze these peptides to the level of free amino acids. In the search, for such downstream proteases, a high-molecular-weight protease complex, called trilobed protease (TLP) was recently discovered in the archaeon, Pyroccocus furiosus. The crystal structure of the N-terminal, beta-propeller domain of the trilobed protease at 2 A resolution shows, that the trilobed protease utilizes this accessory domain to control, substrate access to the active site. Modelling of the intact TLP monomer, suggests that this protease has an additional side entrance to its active, site as in the DPP-IV or tricorn protease complexes.
+In the proteolytic pathway of prokaryotic and eukaryotic organisms, proteins tagged for proteolysis are firstly shredded into smaller peptides by compartmentalized proteases such as the proteasome complex. Accordingly, a variety of downstream proteases have evolved to further hydrolyze these peptides to the level of free amino acids. In the search for such downstream proteases, a high-molecular-weight protease complex called trilobed protease (TLP) was recently discovered in the archaeon Pyroccocus furiosus. The crystal structure of the N-terminal beta-propeller domain of the trilobed protease at 2 A resolution shows that the trilobed protease utilizes this accessory domain to control substrate access to the active site. Modelling of the intact TLP monomer suggests that this protease has an additional side entrance to its active site as in the DPP-IV or tricorn protease complexes.
 ==About this Structure==
@@ Line 15: / Line 15: @@
 [[Category: Baumeister, W.]]
 [[Category: Bosch, J.]]
-[[Category: Essen, L.O.]]
+[[Category: Essen, L O.]]
 [[Category: Tamura, N.]]
 [[Category: Tamura, T.]]
@@ Line 21: / Line 21: @@
 [[Category: open velcro]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 20:04:42 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:33:47 2008''