3vub: Difference between revisions

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{{Seed}}
[[Image:3vub.png|left|200px]]
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{{STRUCTURE_3vub|  PDB=3vub  |  SCENE=  }}  
{{STRUCTURE_3vub|  PDB=3vub  |  SCENE=  }}  
===CCDB, A TOPOISOMERASE POISON FROM E. COLI===
===CCDB, A TOPOISOMERASE POISON FROM E. COLI===
{{ABSTRACT_PUBMED_9917404}}


 
==Function==
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[[http://www.uniprot.org/uniprot/CCDB_ECOLI CCDB_ECOLI]] Toxic component of a toxin-antitoxin (TA) module, functioning in plasmid maintainence. Responsible for the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system. Half-life of over 2 hours. Cell killing by CcdB is accompanied by filamentation, defects in chromosome and plasmid segregation, defects in cell division, formation of anucleate cells, decreased DNA synthesis and plasmid loss. Interferes with the activity of DNA gyrase, inducing it to form a covalent GyrA-DNA complex that cannot be resolved, thus promoting breakage of plasmid and chromosomal DNA. DNA breakage requires hydrolyzable ATP. Toxicity is inhibited by labile antitoxin CcdA, which blocks the activity of CcdB; CcdA also removes bound CcdB protein from the CcdB-GyrA complex by forming a CcdA-CcdB complex, a process termed rejuvenation. Also acts to inhibit partitioning of the chromosomal DNA. Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdA.<ref>PMID:6327993</ref> <ref>PMID:2651399</ref> <ref>PMID:6308648</ref> <ref>PMID:2615761</ref> <ref>PMID:1324324</ref> <ref>PMID:8604132</ref> 
The line below this paragraph, {{ABSTRACT_PUBMED_9917404}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_9917404}}


==About this Structure==
==About this Structure==
3VUB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VUB OCA].  
[[3vub]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VUB OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:9917404</ref><references group="xtra"/>
<ref group="xtra">PMID:009917404</ref><ref group="xtra">PMID:011604529</ref><ref group="xtra">PMID:011917145</ref><ref group="xtra">PMID:019006334</ref><references group="xtra"/><references/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Bahasi, E M.]]
[[Category: Bahasi, E M.]]
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[[Category: Wyns, L.]]
[[Category: Wyns, L.]]
[[Category: Ccdb]]
[[Category: Ccdb]]
[[Category: Plasmid]]
[[Category: Topoisomerase poison]]
[[Category: Topoisomerase poison]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:43:38 2009''
Retrieved from "https://proteopedia.org/3vub"