2gsk: Difference between revisions

[[Image:2gsk.gif|left|200px]]<br /><applet load="2gsk" size="350" color="white" frame="true" align="right" spinBox="true"  

In Gram-negative bacteria, the import of essential micronutrients across the outer membrane requires a transporter, an electrochemical gradient of protons across the inner membrane, and an inner membrane protein complex (ExbB, ExbD, TonB) that couples the proton-motive force to the outer membrane transporter. The inner membrane protein TonB binds directly to a conserved region, called the Ton-box, of the transporter. We solved the structure of the cobalamin transporter BtuB in complex with the C-terminal domain of TonB. In contrast to its conformations in the absence of TonB, the Ton-box forms a beta strand that is recruited to the existing beta sheet of TonB, which is consistent with a mechanical pulling model of transport.

2GSK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CNC:'>CNC</scene>, <scene name='pdbligand=LDA:'>LDA</scene>, <scene name='pdbligand=OCT:'>OCT</scene> and <scene name='pdbligand=HEX:'>HEX</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSK OCA].  

[[Category: Banchs, C N.]]

[[Category: Purdy, M P.]]

[[Category: Shultis, D D.]]

[[Category: Wiener, M C.]]

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