Group:MUZIC: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 15: | Line 15: | ||
One of the functionally most complex sub-compartments of the sarcomere is the Z-disc that forms the lateral boundaries between adjacent sarcomeres. This region plays a central role as the site organizing thick filaments and titin into the molecular machinery that is required for muscle contraction and comprises the actin, titin, and nebulin filaments. | One of the functionally most complex sub-compartments of the sarcomere is the Z-disc that forms the lateral boundaries between adjacent sarcomeres. This region plays a central role as the site organizing thick filaments and titin into the molecular machinery that is required for muscle contraction and comprises the actin, titin, and nebulin filaments. | ||
'''Figure 2''' ''Z-disk ultrastructure. (A) Antiparallel arrangement of actin filaments (grey) interconnected by several layers of α-actinin (green and red) forming an overlapping zigzag like structure (B) The same view rotated by 90deg'' | |||
Thin filaments (actin) from adjacent sarcomeres are anchored at the Z-disc. In this area of the sarcomere, each actin filament overlaps with four filaments from the opposite sarcomere, forming a square lattice, which is cross-connected in a zig-zag pattern by α-actinin-2 <ref>PMID:19830582</ref> ('''Figure 2'''). This region plays a central role as the main anchoring point of the molecular machinery for muscle contraction comprising the actin, titin, and nebulin filaments <ref>PMID:22028589</ref><ref>PMID:9476658</ref>. | Thin filaments (actin) from adjacent sarcomeres are anchored at the Z-disc. In this area of the sarcomere, each actin filament overlaps with four filaments from the opposite sarcomere, forming a square lattice, which is cross-connected in a zig-zag pattern by α-actinin-2 <ref>PMID:19830582</ref> ('''Figure 2'''). This region plays a central role as the main anchoring point of the molecular machinery for muscle contraction comprising the actin, titin, and nebulin filaments <ref>PMID:22028589</ref><ref>PMID:9476658</ref>. | ||
