4hsa: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of interleukin 17a in complex with il17ra receptor===

~~The~~ entry ~~4hsa~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/I17RA_HUMAN I17RA_HUMAN]] Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:[http://omim.org/entry/613953 613953]]. CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.<ref>PMID:21350122</ref>

~~Authors~~: ~~Liu~~, S.

==Function==

[[http://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN]] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. [[http://www.uniprot.org/uniprot/I17RA_HUMAN I17RA_HUMAN]] Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.<ref>PMID:21993848</ref> <ref>PMID:19838198</ref>

~~Description:~~ Structure ~~of interleukin 17a in complex~~ with ~~il17ra~~ receptor

==About this Structure==

[[4hsa]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSA OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Liu, S.]]

[[Category: Cytokine receptor]]

[[Category: Glycosylation]]

[[Category: Immune system-protein binding complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4hsa|  PDB=4hsa  |  SCENE=  }}
+===Structure of interleukin 17a in complex with il17ra receptor===
+{{ABSTRACT_PUBMED_23695682}}
-The entry 4hsa is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/I17RA_HUMAN I17RA_HUMAN]] Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:[http://omim.org/entry/613953 613953]]. CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.<ref>PMID:21350122</ref>
-Authors: Liu, S.
+==Function==
+[[http://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN]] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. [[http://www.uniprot.org/uniprot/I17RA_HUMAN I17RA_HUMAN]] Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.<ref>PMID:21993848</ref> <ref>PMID:19838198</ref>
-Description: Structure of interleukin 17a in complex with il17ra receptor
+==About this Structure==
+[[4hsa]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSA OCA].
+==Reference==
+<ref group="xtra">PMID:023695682</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Liu, S.]]
+[[Category: Cytokine receptor]]
+[[Category: Glycosylation]]
+[[Category: Immune system-protein binding complex]]