3ax1: Difference between revisions
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===Molecular insights into miRNA processing by Arabidopsis Serrate=== | ===Molecular insights into miRNA processing by Arabidopsis Serrate=== | ||
{{ABSTRACT_PUBMED_21685453}} | {{ABSTRACT_PUBMED_21685453}} | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/SRRT_ARATH SRRT_ARATH]] Acts as a mediator between the cap-binding complex (CBC) and both the pre-mRNA splicing and primary microRNAs (miRNAs) processing machinery. Required for proper processing of primary miRNAs to miRNAs, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Does not participate in sense post-transcriptional gene silencing. Acts as a regulator of meristem activity and adaxial leaf fate via the miRNA gene-silencing pathway by regulating the expression of PHB and by limiting the competence of shoot tissue to respond to KNOX expression. Its function is however not limited to miRNA-mediated repression of leaf polarity genes, but rather acts as a general regulator of primary microRNAs processing. Also critical for the accumulation of the trans-acting small interfering RNA (ta-siRNA). Required for pre-mRNA splicing.<ref>PMID:16222298</ref> <ref>PMID:16977334</ref> <ref>PMID:16889646</ref> <ref>PMID:18632569</ref> <ref>PMID:18550839</ref> | |||
==About this Structure== | ==About this Structure== | ||
