2gum: Difference between revisions

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[[Image:2gum.gif|left|200px]]<br /><applet load="2gum" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:2gum.gif|left|200px]]<br /><applet load="2gum" size="350" color="white" frame="true" align="right" spinBox="true"

caption="2gum, resolution 2.10Å" />

'''Crystal structure of the extracellular domain of glycoprotein B from Herpes Simplex Virus type I'''<br />

==Overview==

Glycoprotein B (gB) is the most conserved component of the complex, cell-entry machinery of herpes viruses. A crystal structure of the gB, ectodomain from herpes simplex virus type 1 reveals a multidomain trimer, with unexpected homology to glycoprotein G from vesicular stomatitis virus, (VSV G). An alpha-helical coiled-coil core relates gB to class I viral, membrane fusion glycoproteins; two extended beta hairpins with hydrophobic, tips, homologous to fusion peptides in VSV G, relate gB to class II fusion, proteins. Members of both classes accomplish fusion through a large-scale, conformational change, triggered by a signal from a receptor-binding, component. The domain connectivity within a gB monomer would permit such a, rearrangement, including long-range translocations linked to viral and, cellular membranes.

Glycoprotein B (gB) is the most conserved component of the complex cell-entry machinery of herpes viruses. A crystal structure of the gB ectodomain from herpes simplex virus type 1 reveals a multidomain trimer with unexpected homology to glycoprotein G from vesicular stomatitis virus (VSV G). An alpha-helical coiled-coil core relates gB to class I viral membrane fusion glycoproteins; two extended beta hairpins with hydrophobic tips, homologous to fusion peptides in VSV G, relate gB to class II fusion proteins. Members of both classes accomplish fusion through a large-scale conformational change, triggered by a signal from a receptor-binding component. The domain connectivity within a gB monomer would permit such a rearrangement, including long-range translocations linked to viral and cellular membranes.

==About this Structure==

2GUM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2GUM OCA].

2GUM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] with <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GUM OCA].

==Reference==

Line 13:

[[Category: Human herpesvirus 4]]

[[Category: Single protein]]

[[Category: Heldwein, E.E.]]

[[Category: Heldwein, E E.]]

[[Category: NA]]

[[Category: envelope glycoprotein]]

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[[Category: virus]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 11:24:~~02 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:35:32 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2gum.gif|left|200px]]<br /><applet load="2gum" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:2gum.gif|left|200px]]<br /><applet load="2gum" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="2gum, resolution 2.10&Aring;" />
 '''Crystal structure of the extracellular domain of glycoprotein B from Herpes Simplex Virus type I'''<br />
 ==Overview==
-Glycoprotein B (gB) is the most conserved component of the complex, cell-entry machinery of herpes viruses. A crystal structure of the gB, ectodomain from herpes simplex virus type 1 reveals a multidomain trimer, with unexpected homology to glycoprotein G from vesicular stomatitis virus, (VSV G). An alpha-helical coiled-coil core relates gB to class I viral, membrane fusion glycoproteins; two extended beta hairpins with hydrophobic, tips, homologous to fusion peptides in VSV G, relate gB to class II fusion, proteins. Members of both classes accomplish fusion through a large-scale, conformational change, triggered by a signal from a receptor-binding, component. The domain connectivity within a gB monomer would permit such a, rearrangement, including long-range translocations linked to viral and, cellular membranes.
+Glycoprotein B (gB) is the most conserved component of the complex cell-entry machinery of herpes viruses. A crystal structure of the gB ectodomain from herpes simplex virus type 1 reveals a multidomain trimer with unexpected homology to glycoprotein G from vesicular stomatitis virus (VSV G). An alpha-helical coiled-coil core relates gB to class I viral membrane fusion glycoproteins; two extended beta hairpins with hydrophobic tips, homologous to fusion peptides in VSV G, relate gB to class II fusion proteins. Members of both classes accomplish fusion through a large-scale conformational change, triggered by a signal from a receptor-binding component. The domain connectivity within a gB monomer would permit such a rearrangement, including long-range translocations linked to viral and cellular membranes.
 ==About this Structure==
-GUM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2GUM OCA].
+GUM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] with <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GUM OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Human herpesvirus 4]]
 [[Category: Single protein]]
-[[Category: Heldwein, E.E.]]
+[[Category: Heldwein, E E.]]
 [[Category: NA]]
 [[Category: envelope glycoprotein]]
@@ Line 19: / Line 19: @@
 [[Category: virus]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 11:24:02 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:35:32 2008''