2gx9: Difference between revisions
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New page: left|200px<br /><applet load="2gx9" size="350" color="white" frame="true" align="right" spinBox="true" caption="2gx9, resolution 2.100Å" /> '''X-ray strucutre of ... |
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==Overview== | ==Overview== | ||
The nonstructural protein NS1 of influenza virus is an antagonist of host | The nonstructural protein NS1 of influenza virus is an antagonist of host immune responses and is implicated in virulence. It has two domains, an N-terminal double-stranded RNA-binding domain (RBD) and an effector domain crucial for RBD function, for nuclear export and for sequestering messenger RNA-processing proteins. Here we present the crystallographic structure of the effector domain, which has a novel fold and suggests mechanisms for increased virulence in H5N1 strains. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Unidentified influenza virus]] | [[Category: Unidentified influenza virus]] | ||
[[Category: Bornholdt, Z | [[Category: Bornholdt, Z A.]] | ||
[[Category: Prasad, B | [[Category: Prasad, B V.]] | ||
[[Category: SCN]] | [[Category: SCN]] | ||
[[Category: alpha-helix beta-crescent]] | [[Category: alpha-helix beta-crescent]] | ||
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[[Category: ns1]] | [[Category: ns1]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:36:18 2008'' | ||
