2h02: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: left|200px<br /> <applet load="2h02" size="450" color="white" frame="true" align="right" spinBox="true" caption="2h02, resolution 2.300Å" /> '''Structural studies... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2h02.gif|left|200px]]<br /> | [[Image:2h02.gif|left|200px]]<br /><applet load="2h02" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2h02" size=" | |||
caption="2h02, resolution 2.300Å" /> | caption="2h02, resolution 2.300Å" /> | ||
'''Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors'''<br /> | '''Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors'''<br /> | ||
==Overview== | ==Overview== | ||
The sulfamic acid phosphotyrosine mimetic was coupled with a previously | The sulfamic acid phosphotyrosine mimetic was coupled with a previously known malonate template to obtain highly selective and potent inhibitors of HPTPbeta. Potentially hydrolyzable malonate ester functionalities were replaced with 1,2,4-oxadiazoles without a significant effect on HPTPbeta potency. | ||
==About this Structure== | ==About this Structure== | ||
2H02 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 2UN as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http:// | 2H02 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=2UN:'>2UN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H02 OCA]. | ||
==Reference== | ==Reference== | ||
| Line 15: | Line 14: | ||
[[Category: Protein-tyrosine-phosphatase]] | [[Category: Protein-tyrosine-phosphatase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Amarasinghe, K | [[Category: Amarasinghe, K D.]] | ||
[[Category: Clark, C | [[Category: Clark, C M.]] | ||
[[Category: Evdokimov, A | [[Category: Evdokimov, A G.]] | ||
[[Category: Gray, J | [[Category: Gray, J L.]] | ||
[[Category: Maier, M | [[Category: Maier, M B.]] | ||
[[Category: Mekel, M.]] | [[Category: Mekel, M.]] | ||
[[Category: Nichols, R.]] | [[Category: Nichols, R.]] | ||
[[Category: Peters, K | [[Category: Peters, K G.]] | ||
[[Category: Pokross, M | [[Category: Pokross, M E.]] | ||
[[Category: Walter, R | [[Category: Walter, R L.]] | ||
[[Category: 2UN]] | [[Category: 2UN]] | ||
[[Category: drug design]] | [[Category: drug design]] | ||
| Line 33: | Line 32: | ||
[[Category: wpd-loop]] | [[Category: wpd-loop]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:36:47 2008'' | ||
