2h3d: Difference between revisions
New page: left|200px<br /><applet load="2h3d" size="450" color="white" frame="true" align="right" spinBox="true" caption="2h3d, resolution 2.10Å" /> '''Crystal Structure of... |
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[[Image:2h3d.gif|left|200px]]<br /><applet load="2h3d" size=" | [[Image:2h3d.gif|left|200px]]<br /><applet load="2h3d" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2h3d, resolution 2.10Å" /> | caption="2h3d, resolution 2.10Å" /> | ||
'''Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor in Complex with Nicotinamide Mononuleotide'''<br /> | '''Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor in Complex with Nicotinamide Mononuleotide'''<br /> | ||
==Overview== | ==Overview== | ||
Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide | Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism. | ||
==About this Structure== | ==About this Structure== | ||
2H3D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NMN as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] Full crystallographic information is available from [http:// | 2H3D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NMN:'>NMN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3D OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bheda, P.]] | [[Category: Bheda, P.]] | ||
[[Category: Imai, S | [[Category: Imai, S I.]] | ||
[[Category: Revollo, J | [[Category: Revollo, J R.]] | ||
[[Category: Wang, T.]] | [[Category: Wang, T.]] | ||
[[Category: Wolberger, C.]] | [[Category: Wolberger, C.]] | ||
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[[Category: typeii phsophoribosyltransferase]] | [[Category: typeii phsophoribosyltransferase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:37:46 2008'' | ||
Revision as of 15:37, 21 February 2008
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Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor in Complex with Nicotinamide Mononuleotide
Overview
Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.
About this Structure
2H3D is a Single protein structure of sequence from Mus musculus with NMN as ligand. Active as Nicotinamide phosphoribosyltransferase, with EC number 2.4.2.12 Full crystallographic information is available from OCA.
Reference
Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme., Wang T, Zhang X, Bheda P, Revollo JR, Imai S, Wolberger C, Nat Struct Mol Biol. 2006 Jul;13(7):661-2. Epub 2006 Jun 18. PMID:16783373
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