Pteridine reductase

<StructureSection load='1mxh' size='350' side='right' caption='Structure of pteridine reductase complex with NADPH and folate(PDB entry 1mxh)' scene=>

Pteridine reductase (PTR) catalyzes the reduction of 5,6,7,8-tetrahydrobiopterin (THBP) to biopterin. PTR is part of pterin and folate metabolism. NADP is the hydrogen acceptor in this reduction. PTR is essential for growth of trypanosomatid protozoans like Leishmania parasites, thus PTR inhibitors like methotrexate (MTX) or triaminoquinazoline (TAQ) are tested as potential drugs.

3D structures of pteridine reductase

Updated on 19-June-2013

2xox – LdPTR1 (mutant) – Leishmania donovani
2bfo – LmPTR1 + NADPH – Leishmania major

Pteridine reductase complex with inhibitor

1e7w – LmPTR1 + NADPH + MTX
1w0c – LmPTR1 + NADPH + TAQ
1p33 – PTR1 + NADPH + MTX – Leishmania tarentolae
1mxf – TcPTR2 + NADPH + MTX – Trypanosoma cruzi
2c7v – TbPTR1 + NADPH + MTX – Trypanosoma brucei
3bmn, 3bmo, 3bmq, 2wd7, 2wd8, 2vz0, 3jq6, 3jq7, 3jq8, 3jq9, 3jqa, 3jqb, 3jqc, 3jqf, 3jqd, 3jqe, 3jqg, 3gn1, 3gn2, 3mcv, 2x9g, 2x9v, 2x9n, 2yhi, 2yhu – TbPTR1 + NADPH + inhibitor
2bfa, 2bfm, 3h4v – LmPTR1 + NADPH + inhibitor

Pteridine reductase complex with ligand

2bfp – LmPTR1 + NADPH + THBP
2qhx – LmPTR1 + NADPH + ligand
1e92, 2bf7 – LmPTR1 + NADPH + DHBP
1mxh – TcPTR1 + NADPH + folate
3bmc – TbPTR1 + NADPH + folate

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Michal Harel, Alexander Berchansky, Joel L. Sussman