4fia: Difference between revisions
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{{STRUCTURE_4fia| PDB=4fia | SCENE= }} | {{STRUCTURE_4fia| PDB=4fia | SCENE= }} | ||
===Crystal Structure of Human CYP46A1 P450 with bicalutamide Bound=== | ===Crystal Structure of Human CYP46A1 P450 with bicalutamide Bound=== | ||
{{ABSTRACT_PUBMED_23288837}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CP46A_HUMAN CP46A_HUMAN]] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. | |||
==About this Structure== | ==About this Structure== | ||
[[4fia]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FIA OCA]. | [[4fia]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FIA OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023288837</ref><references group="xtra"/><references/> | |||
[[Category: Cholesterol 24-hydroxylase]] | [[Category: Cholesterol 24-hydroxylase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 13:29, 19 June 2013
Crystal Structure of Human CYP46A1 P450 with bicalutamide Bound
Template:ABSTRACT PUBMED 23288837
Function
[CP46A_HUMAN] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.
About this Structure
4fia is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Mast N, Zheng W, Stout CD, Pikuleva IA. Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response. J Biol Chem. 2013 Feb 15;288(7):4613-24. doi: 10.1074/jbc.M112.438754. Epub 2013 , Jan 3. PMID:23288837 doi:10.1074/jbc.M112.438754
