4eda: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structures of monomeric hemagglutinin and its complex with an Fab fragment of a neutralizing antibody that binds to H1 subtype influenza viruses: molecular basis of infectivity of 2009 pandemic H1N1 influenza A viruses===

~~The entry 4eda is ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/C5MQE6_9INFA C5MQE6_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]

~~Authors~~: ~~Kim, K~~.H.~~, Cho, K~~.~~J., Lee, J.H., Park, Y.H., Khan, T.G., Lee, J.Y~~.~~, Kang, S~~.H.~~, Alam, I~~.

==About this Structure==

[[4eda]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/korea/01/2009(h1n1)) Influenza a virus (a/korea/01/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDA OCA].

~~Description~~: ~~Structures of monomeric hemagglutinin and its complex with an Fab fragment of a neutralizing antibody that binds to H1 subtype influenza viruses~~: ~~molecular basis of infectivity of 2009 pandemic H1N1 influenza A viruses~~

==Reference==

[[Category: Alam, I.]]

[[Category: Cho, K J.]]

[[Category: Kang, S H.]]

[[Category: Khan, T G.]]

[[Category: Kim, K H.]]

[[Category: Lee, J H.]]

[[Category: Lee, J Y.]]

[[Category: Park, Y H.]]

[[Category: Antibody]]

[[Category: Conformation]]

[[Category: Haemagglutinin]]

[[Category: Influenza virus]]

[[Category: Viral protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4eda|  PDB=4eda  |  SCENE=  }}
+===Structures of monomeric hemagglutinin and its complex with an Fab fragment of a neutralizing antibody that binds to H1 subtype influenza viruses: molecular basis of infectivity of 2009 pandemic H1N1 influenza A viruses===
+{{ABSTRACT_PUBMED_23636824}}
-The entry 4eda is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/C5MQE6_9INFA C5MQE6_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
-Authors: Kim, K.H., Cho, K.J., Lee, J.H., Park, Y.H., Khan, T.G., Lee, J.Y., Kang, S.H., Alam, I.
+==About this Structure==
+[[4eda]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/korea/01/2009(h1n1)) Influenza a virus (a/korea/01/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDA OCA].
-Description: Structures of monomeric hemagglutinin and its complex with an Fab fragment of a neutralizing antibody that binds to H1 subtype influenza viruses: molecular basis of infectivity of 2009 pandemic H1N1 influenza A viruses
+==Reference==
+<ref group="xtra">PMID:023636824</ref><references group="xtra"/><references/>
+[[Category: Alam, I.]]
+[[Category: Cho, K J.]]
+[[Category: Kang, S H.]]
+[[Category: Khan, T G.]]
+[[Category: Kim, K H.]]
+[[Category: Lee, J H.]]
+[[Category: Lee, J Y.]]
+[[Category: Park, Y H.]]
+[[Category: Antibody]]
+[[Category: Conformation]]
+[[Category: Haemagglutinin]]
+[[Category: Influenza virus]]
+[[Category: Viral protein]]