4gj3: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide===

~~The~~ entry ~~4gj3 is ON HOLD until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[http://omim.org/entry/611521 611521]]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.

~~Authors~~: ~~Ultsch, M~~.H

==Function==

[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref>

~~Description~~: ~~Tyk2 (JH1) in~~ complex ~~with compound 35~~

==About this Structure==

[[4gj3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GJ3 OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Non-specific protein-tyrosine kinase]]

[[Category: Ultsch, M H.]]

[[Category: Atp binding]]

[[Category: Kinase]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4gj3|  PDB=4gj3  |  SCENE=  }}
+===Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide===
+{{ABSTRACT_PUBMED_23668484}}
-The entry 4gj3 is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[http://omim.org/entry/611521 611521]]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
-Authors: Ultsch, M.H
+==Function==
+[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref>
-Description: Tyk2 (JH1) in complex with compound 35
+==About this Structure==
+[[4gj3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GJ3 OCA].
+==Reference==
+<ref group="xtra">PMID:023668484</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Non-specific protein-tyrosine kinase]]
+[[Category: Ultsch, M H.]]
+[[Category: Atp binding]]
+[[Category: Kinase]]
+[[Category: Transferase-transferase inhibitor complex]]