4imo: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069===

~~The entry 4imo~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN]] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref>

~~Authors~~: ~~Lim, S~~.M.~~, Chen, D~~.~~, Teo, H., Roos, A., Nyman, T~~.~~, Tresaugues, L~~.~~, Pervushin, K~~.~~, Nordlund, P~~.

==About this Structure==

[[4imo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMO OCA].

~~Description~~: ~~Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Prostaglandin-D synthase]]

[[Category: Chen, D.]]

[[Category: Lim, S M.]]

[[Category: Nordlund, P.]]

[[Category: Nyman, T.]]

[[Category: Pervushin, K.]]

[[Category: Roos, A.]]

[[Category: Teo, H.]]

[[Category: Tresaugues, L.]]

[[Category: Beta barrel]]

[[Category: Endoplasmic reticulum]]

[[Category: Isomerase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4imo|  PDB=4imo  |  SCENE=  }}
+===Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069===
+{{ABSTRACT_PUBMED_23526831}}
-The entry 4imo is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN]] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref>
-Authors: Lim, S.M., Chen, D., Teo, H., Roos, A., Nyman, T., Tresaugues, L., Pervushin, K., Nordlund, P.
+==About this Structure==
+[[4imo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMO OCA].
-Description: Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069
+==Reference==
+<ref group="xtra">PMID:023526831</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Prostaglandin-D synthase]]
+[[Category: Chen, D.]]
+[[Category: Lim, S M.]]
+[[Category: Nordlund, P.]]
+[[Category: Nyman, T.]]
+[[Category: Pervushin, K.]]
+[[Category: Roos, A.]]
+[[Category: Teo, H.]]
+[[Category: Tresaugues, L.]]
+[[Category: Beta barrel]]
+[[Category: Endoplasmic reticulum]]
+[[Category: Isomerase]]